clinicalkey

Medical Sciences

Breast Cancer

Past, Present and Future

Breast carcinoma is among the most frequent malignant diseases in the world and is the leading cause of death among younger women in developed countries. Currently, 1 in 7 woman in these countries will have the disease in their lifetime (Boyle and Ferlay). Since 1940, the incidence of breast carcinoma has gradually increased at a rate of approximately 1 per cent per year in Western countries (Harris et al.).


Back Pain and Treatment Options

LBP is one of the most common pain complaint and usually one of the hardest syndromes to treat. Interventional pain management offers an opportunity to assist in the diagnosis and management of back pain.


Telemedicine

Using the Example of Practical Models of Healthcare with Cardiovascular Disease

Technical progress, statistical evidence of significant increases in therapeutic success, as well as the participation of an increasing number of ambulatory physicians has made telemedicine successful.


Advanced Diabetes Care

Moving from delayed interventional to predictive, preventive and personalised medicine

Advanced diabetes care requires the creation of new guidelines, timely predictive diagnostics, effective prevention and creation of individualised treatment algorithms.


Circulating Nucleic Acids in Plasma & Serum

A non-invasive approach

CNAPS offers a non-invasive approach to a wide range of clinical disorders that will allow the basic information necessary not only for use in predictive medicine but also for direct use in acute medicine.


Bariatric and Metabolic Surgery

Anaesthesia concerns

As it has been realized that western diagnosis criteria for obese and metabolic syndrome do not hold true for Asian patients, anaesthesia care providers should be completely aware of the pathphysiology, risks and difficulties encountered by obese patients during the bariatric surgeries.


Stroke Assessment

A medical emergency

Early recognition of stroke signs and symptoms by the public and professionals, rapid transfer of the stroke patient to hospital, early stroke specialist assessment and treatment including thrombolysis and transfer to a specialist acute stroke unit are all evidence-based interventions leading to improved outcome with lower disability and mortality from stroke.


Transcriptional Control of Heart Failure

Recent developments

Heart failure is a major health problem worldwide. Current therapies manage the symptoms of heart failure. New experimental findings suggest possible future therapies that arrest the development of heart failure.


Importance of Traditional Medicine

In the age of technology

Most nations, except the US, have natural medicine traditions known and widely practised by the populace. With the increasing availability of Western technocentred medicine, there’s a seduction in favour of ‘modern’ medicine over traditional treatments. Health outcomes in the US indicate the risks on this path and the importance of staying patient-centred.


Contrast Echocardiography

Current indications

Contrast agents have been shown to be useful to improve the image quality in echocardiography. The development of new ultrasound contrast agents and imaging techniques has enabled the bedside assessment of myocardial function and perfusion.


Heart Failure Management

Monitoring with implantable devices

Implantable devices, including pacemakers, defibrillators and cardiac resynchronisation systems, may play a role in helping monitor the progress of heart failure in an individual patient.


Treatment of Stroke

Acting on the symptoms

Prompt recognition of suspected stroke symptoms and immediate activation of Emergency Medical Services (EMS) are crucial to effective pre-hospital stroke care, early access to stroke specialist services and successful management.


Advanced Colorectal Cancer

Improving the survival rate

The management of Colorectal Cancer liver metastases has evolved over the past decade as a result of using more sophisticated imaging technology, effective systemic therapies including multi-drug treatment regimes with advanced surgical techniques. This has greatly improved response rates, resectability rates and in turn survival.


Chronic Pain Management

With the number of individuals in need of assistance for chronic pain increasing each year, only a small fraction of patients with chronic pain are treated directly by the Pain Clinic.


Slow Medicine

Emerging concept in elderly care

The patient’s perspective is always, always central to the practice of Slow Medicine.


Slow Medicine

A compassionate approach to elderly care


Cardiac Death Predisposition

New tools for early detection

Those who die a sudden death, probably are never aware of the potential risk they carry. Recently, new tools for diagnosing those prone to SCD have been introduced. This marks a key milestone in the detection of sudden cardiac death signs among healthy individuals.


The Changing Face of Cancer

Implications for Anaesthesia

Given the unique skills of anaesthesiologists in pain management and regional anaesthesia, the role of anaesthesiologists is increasing in the care of cancer patients.


Multidisciplinary Collaboration in the ICU

Promoting effective care

Collaboration and communication among all the team members of the Intensive Care Unit (ICU), where patient activity is high, goes a long way in promoting effective care of critically ill patients.


Targeting the Stress of Diabetes

Preserving vascular longevity

Diabetes Mellitus occurs in more than 165 million individuals worldwide and leads to both acute and long-term cardiovascular complications that can be tied to cellular oxidative stress. Three exciting novel therapeutic strategies offer significant promise to extend vascular longevity.


Embolic Protection During Carotid Stenting

Using FiberNet device

The FiberNet device is the first embolic protection device, which combines features of a filter, and an occlusion device in one system to overcome the complications of carotid angioplasty like distal embolisation of debris.


Safety in Anaesthesia

Promoting sustainable change for the future

The future of safety in anaesthesia lies partly in technological advances in countries that can afford them. The priority, however, is to address the unacceptable deficiencies in anaesthesia services globally.


Telemonitoring in Cardiac Device Therapy

Enabling optimal management of patients

The vastly increased complexity of cardiac rhythm therapy over the past several years, demands commensurate improvements in overall device monitoring and telecommunication technology.


Treating Lung Cancer

Immunotherapeutic strategies

New treatment modalities such as immunotherapeutic strategies may help improve the currently poor prognosis and outcome of patients suffering from lung cancer. However, thus far, lung cancer has not been considered an immune-sensitive malignancy. Now, there is an increasing evidence that specific humeral and cellular anti-tumour immune responses can be evoked.


Truth in Ethics, Truth in Science - Different?

The notion of truth is same in ethics and science. However, the data in science and ethics are different. In science we rely on observation, in ethics we rely on considered moral intuitions. There is little agreement about when we should trust our ethical intuitions. It is remarkable, however, that neuroscience and psychology has recently shed new light on how our moral intuitions arise.


Genetic Tests

All about interpreting

Profiling can be inherently valuable, but we must keep it in the perspective of the entire picture of a person's health, lifestyle, environmental factors, and the like.


Genetic Tests

The ethics side

The industry should be addressing these issues right now. Ethics is the biggest obstacle to the future success of genetic testing.


Genetic Tests

All set for growth

Technology and the worldwide coordination of efforts to push discovery in genetics has exacerbated the growth of opportunity in this sector.


Personalised Medicine

An idea whose time is approaching

DNA sequencing of human genes could provide the 21st century with the ultimate in evidence-based medicine allowing us to tackle not only cardiovascular disease, but many other life threatening diseases.


Personalised Medicine

Future architecture

The standard “one size fits all” approach of treating many individuals may soon become obsolete. More targeted approaches promise to improve outcomes while reducing toxicity and medical costs.


Convergence in the Life Sciences Industry

Combination products show the way

Driven by market forces, a need for new growth avenues and an ever more conscious consumer, medical device, pharma and diagnostics companies are coming together to deliver innovative solutions.


Stem Cell Therapy

The good, the bad and the confusing

Stem cell therapies offer great potential for treating diseases. However, a lot of questions remain to be answered before this potential can be realised.


New Drugs in Anaesthesia

A review

New drugs are being developed in anaesthesia, so as to reduce the number of side-effects and to improve patient outcome.


Cancer Nanomedicine

Emerging Opportunities

Nanotechnology has many advantages when applied to medicine. However, continued research into disease processes at the molecular level is essential for its development.


Cancer

Early detection strategies

Using biomarkers representing protien with diffrent biological functions will allow complimentarity in cancer detection, resulting in increased sensitivity without compromising specificity.


Cardiac Surgery

New techniques

The focus of new techniques has been on making cardiac surgery safe, minimally invasive and cost-effective.


Anaesthesia

The 21st century challenge

The challenge for the 21st century anaesthesia leaders will be to bridge the widening gap in practice and education within the speciality whilst at the same time increasing its safety.


Type-2 Diabetes in India

India has approximately 33 million diabetic subjects today and the number is expected to rise to 57.9 million by 2025. More than 95 per cent of them belong to the type - 2 diabetes category.


Pain Relief in Childhood

To make a uniform level of pain relief available around the world may not be possible.


Changing Landscapes in Anaesthesia

A number of changes have occured concurrently in the field of surgery and anaesthesia.


Automated Defibrillation Saves Lives

Heart disease is the second most common cause of death in Singapore today, comprising about 20 per cent of all deaths in the country in the year 2004.


Cardiovascular Disease and Renal Failure

Death from cardiovascular disease (CVD) in end-stage renal failure (ESRF) is 20 to 40 times higher than in the general population.


Superior Dose Delivery

Over time, the characteristics of the acute renal failure (ARF) patient population in the ICU have changed considerably...


Genetic Influence on Glomerulonephritis

Human genetics studies reveal that all genes comprising the renin-angiotensin system (RAS) have several forms of polymorphism...


The New Mind Readers

Mind-reading might sound like sci-fi stuff.Not any more, if indications from studies by two groups from Vanderbilt University, Nashville...


Renal Care and Blood Component Technology

In Haemodialysis(HD) the Blood is Conducted, VIA Blood Lines outside the body and through the dialyser, where the purification takes place.


The Challenges of Intensive Care

In the Asian context, intensive care medicine is a relatively new speciality. Although there has been a major thrust to improve the delivery of healthcare, the main focus has been on improving primary healthcare.


Memory, Awareness and Depth of Anaesthesia

Anaesthesia has been defined as the state in which, as a result of drug-induced unconsciousness, the patient neither perceives nor recalls noxious stimuli.


Diagnostic imaging in Asia

Radiology is experiencing higher productivity from new-generation equipment that provides many more images in a shorter time than older equipment.


Advances in CT Technology

Multi-slice, wide-bore CT scanning has arrived for oncology applications, allowing greater visibility at a higher resolution than was possible before.


The Menace of Antibiotic Resistance

As antibiotic-resistant strains of bacteria continue to emerge, the need to develop new antibiotics has become urgent.


Restoring People to Full Life

Medtronic's Cardiac Rhythm Management is focused on managing the entire spectrum of cardiac rhythm disorders to improve long-term patient care.


The Road To Digital Imaging

In a time of change and transition, radiology equipment needs to be flexible enough to meet both current and future needs

A Multi-Tasking AT1 Receptor Blocker

Adverse effects of increased angiotensin II levels and catecholamines have traditionally been considered as two different therapeutic targets.



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