Multi-detector CT Perfusion As A Diagnostic Imaging Modality To Evaluate Local Therapy Of Hepatocellular Carcinoma

Authors: Ashraf M. Enitea, Hazem Rabeeb

Abstract:

Objective:

To evaluate MDCT perfusion role in HCC local therapy response.

Keywords

HCC, hepatocellular carcinoma; RFA, radiofrequency ablation; TACE, trans-arterial chemoembolization; TDC, time density curve; CTP, volume perfusion MDCT.

Patients and methods

Post radiofrequency ablation and trans-arterial chemoembolization 14 (88%) male and 2 (12%) female HCC patients; with the mean age, 55.75 ± 10.6 years underwent follow-up hepatic CT perfusion. The hepatic arterial and portal venous perfusions (HAP and HPP, ml/min/100 ml) and hepatic perfusion index (HPI%) were indicated using the color coded maps to assess the effects of local therapy on hepatic perfusion values.

Results

The post local treatment CTP of the recurrent tumor confirmed relative increased HAP and HPI and reduced PVP relative to the background values of the cirrhotic hepatic parenchyma. The recurrent HCC post-treatment CTP including HAP is 71 ± 12.19, the PVP is 25.5 ± 8.66 and HPI is 52.5 ± 11.9. The post local-treatment CTP of the necrosis confirmed relative decreased HAP and HPI and increased PVP. The post-treatment necrosis CTP including HAP is 23 ± 10.39, the PVP is 34.75 ± 11.5 and HPI is 29 ± 16.51. The CTP sensitivity is 75%, specificity 50% and P-value <0.05.

Citation: Ashraf M. Enitea, Hazem Rabeeb Multi-detector Ct Perfusion As A Diagnostic Imaging Modality To Evaluate Local Therapy Of Hepatocellular Carcinoma doi:10.1016/j.ejrnm.2016.04.004

Received: 8 January 2016, Accepted: 3 April 2016, Available online: 19 April 2016

Copyright: © 2016 The Egyptian Society of Radiology and Nuclear Medicine. Production and hosting by Elsevier B.V.  This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Conclusion

CTP is a promising non-invasive technique assessing the efficacy, predicting early response to local treatment therapies and monitoring tumor recurrence. It assesses the degree of post therapy tumor perfusion especially the degree of arterialization.

Conflict of interest

The authors declare that there are no conflict of interests.