Research Insights

This section focusses on the cutting-edge research and findings in the various disciplines of healthcare around the world.

Pulmonary vascular dysfunction among people aged over 65 years in the community in the Atherosclerosis Risk In Communities (ARIC) Study: A cross-sectional analysis

Heart failure HF risk is highest in late life and impaired pulmonary vascular function is a risk factor for HF development However data regarding the contributors to and prognostic importance of pulmonary vascular dysfunction among HFfree elders in the community are limited and largely restricted to pulmonary hypertension

Evidences of histologic thrombotic microangiopathy and the impact in renal outcomes of patients with IgA nephropathy

IgA nephropathy IgAN is the most common primary glomerulopathy worldwide According to the Oxford Classification changes in the kidney vascular compartment are not related with worse outcomes This paper aims to assess the impact of thrombotic microangiopathy

Systematic review of pre-clinical therapies for post-operative atrial fibrillation

Postoperative atrial fibrillation POAF is a frequent cardiothoracic surgery complication that increases hospital stay mortality and costs Despite decades of research there has been no systematic overview and metaanalysis of preclinical therapies for POAF in animal models

Assessing the health status and mortality of older people over 65 with HIV

Nearly half of people with HIV in the United States are years or older and this proportion is growing Between and the largest percent increase in the prevalence rate of HIV was among people aged and older the eligibility age for Medicare coverage for individuals without a disability

Genetics of height and risk of atrial fibrillation: A Mendelian randomization study

Observational studies have identified height as a strong risk factor for atrial fibrillation but this finding may be limited by residual confounding We aimed to examine genetic variation in height within the Mendelian randomization MR framework to determine whether height has a causal

Primary healthcare expansion and mortality in Brazil’s urban poor: A cohort analysis of 1.2 million adults

Expanding delivery of primary healthcare to urban poor populations is a priority in many low and middleincome countries This remains a key challenge in Brazil despite expansion of the countrys internationally recognized Family Health Strategy FHS over the past two decades This study evaluates the impact of an ambitious program to rapidly expand FHS

Defining remission of type 2 diabetes in research studies: A systematic scoping review

Remission has been identified as a top priority by people with type diabetes Remission is commonly used as an outcome in research studies however a widely accepted definition of remission of type diabetes is lacking A report on defining remission was published

Metabolically healthy obesity, transition to unhealthy metabolic status, and vascular disease in Chinese adults: A cohort study

Metabolically healthy obesity MHO and its transition to unhealthy metabolic status have been associated with risk of cardiovascular disease CVD in Western populations However it is unclear to what extent metabolic health changes over time and whether such transition affects risks of subtypes of CVD in Chinese adults

Acute kidney injury associated with COVID-19: A retrospective cohort study

Initial reports indicate a high incidence of acute kidney injury AKI in Coronavirus Disease COVID but more data are required to clarify if COVID is an independent risk factor for AKI and how COVIDassociated AKI may differ from AKI due to other causes We therefore sought to study the relationship between COVID

Bone marrow microenvironments that contribute to patient outcomes in newly diagnosed multiple myeloma: A cohort study of patients in the Total Therapy clinical trials

The tumor microenvironment TME is increasingly appreciated as an important determinant of cancer outcome including in multiple myeloma MM However most myeloma microenvironment studies have been based on bone marrow BM aspirates which often do not fully reflect the cellular content of BM tissue itself To address this limitation

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