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Research Insights

This section focusses on the cutting-edge research and findings in the various disciplines of healthcare around the world.

Alcoholic liver disease: A registry view on comorbidities and disease prediction

Alcoholicrelated liver disease ALD is the cause of more than half of all liverrelated deaths Sustained excess drinking causes fatty liver and alcoholrelated steatohepatitis which may progress to alcoholic liver fibrosis ALF and eventually to alcoholrelated liver cirrhosis ALC Unfortunately it is difficult to identify patients with earlystage

Identifying locations of re-entrant drivers from patient-specific distribution of fibrosis in the left atrium

Clinical evidence suggests a link between fibrosis in the left atrium LA and atrial fibrillation AF the most common sustained arrhythmia Imagederived fibrosis is increasingly used for patient stratification and therapy guidance However locations of reentrant drivers RDs sustaining AF are unknown and therapy success rates remain suboptimal

Models of SIV Rebound After Treatment Interruption That Involve Multiple Reactivation Events

In order to assess the efficacy of novel HIV treatments leading to a functional cure the time to viral rebound is frequently used as a surrogate endpoint The longer the time to viral rebound the more efficacious the therapy In support of such an approach mathematical models serve as a connection

A Mathematical Model of the Metastatic Bottleneck Predicts Patient Outcome and Response to Cancer Treatment

Metastases are the main reason for cancerrelated deaths Initiation of metastases where newly seeded tumor cells expand into colonies presents a tremendous bottleneck to metastasis formation Despite its importance a quantitative description of metastasis initiation and its clinical implications is lacking

Mathematical model predicts response to chemotherapy in advanced non-resectable non-small cell lung cancer patients treated with platinum-based doublet

We developed a computational platform including machine learning and a mechanistic mathematical model to find the optimal protocol for administration of platinumdoublet chemotherapy in a palliative setting The platform has been applied to advanced metastatic nonsmall cell lung cancer NSCLC

Machine learning to predict mesenchymal stem cell efficacy for cartilage repair

Inconsistent therapeutic efficacy of mesenchymal stem cells MSCs in regenerative medicine has been documented in many clinical trials Precise prediction on the therapeutic outcome of a MSC therapy based

Cardiac and renal function interactions in heart failure with reduced ejection fraction: A mathematical modeling analysis

Congestive heart failure is characterized by suppressed cardiac output and arterial filling pressure leading to renal retention of salt and water contributing to further volume overload Mathematical modeling provides a means to investigate the integrated function

Disparities in United States hospitalizations for serious infections in patients with and without opioid use disorder: A nationwide observational study

Patients with opioid use disorder OUD who are hospitalized for serious infections requiring prolonged intravenous antibiotics may face barriers to discharge which could prolong hospital length of stay LOS and increase financial burden

Psychological and pharmacological interventions for posttraumatic stress disorder and comorbid mental health problems following complex traumatic events

Complex traumatic events associated with armed conflict forcible displacement childhood sexual abuse and domestic violence are increasingly prevalent People exposed to complex traumatic events are at risk of not only posttraumatic stress disorder

Age and the association between apolipoprotein E genotype and Alzheimer disease: A cerebrospinal fluid biomarker–based case–control study

The allele of apolipoprotein E APOE gene and increasing age are two of the most important known risk factors for developing Alzheimer disease AD The diagnosis of AD based on clinical symptoms alone is known to have poor specificity

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