Research Insights

This section focusses on the cutting-edge research and findings in the various disciplines of healthcare around the world.

The Effects of Implementing a Point-of-Care Electronic Template to Prompt Routine Anxiety and Depression Screening in Patients Consulting for Osteoarthritis (the Primary Care Osteoarthritis Trial): A cluster randomised trial in primary care

Abstract Background This study aimed to evaluate whether prompting general practitioners GPs to routinely assess and manage anxiety and depression in patients consulting with osteoarthritis OA improves pain outcomes Methods and findings We conducted a cluster randomised controlled trial involvin..

Patterns of Immune Infiltration in Breast Cancer and Their Clinical Implications: A Gene-Expression-Based Retrospective Study

Abstract Background Immune infiltration of breast tumours is associated with clinical outcome However past work has not accounted for the diversity of functionally distinct cell types that make up the immune response The aim of this study was to determine whether differences in the cellular compos..

Rapid Molecular Diagnostic Test For Zika Virus With Low Demands On Sample Preparation And Instrumentation

Abstract Zika virus has only recently gained attention due to recent large outbreaks worldwide An easy to use nucleic acid amplification test could play an important role in the early detection of the infection and patient management Here we report a rapid and robust isothermal nucleic acid amplifi..

Zika Virus Outbreak And The Case For Building Effective And Sustainable Rapid Diagnostics Laboratory Capacity Globally

New and reemerging pathogens with epidemic potential have threatened global health security for the past century1 As with the recent Ebola Virus Disease EVD epidemic the Zika Virus ZIKV outbreak has yet again surprised and overwhelmed the international health community with an unexpected event for w..

Real-Time Magnetic Resonance Imaging Guidance Improves the Diagnostic Yield of Endomyocardial Biopsy

Summary Diagnostic yield of endomyocardial biopsy is low particularly in disease that affects the myocardium in a nonuniform distribution The authors hypothesized that realtime MRI guidance could improve the yield through targeted biopsy of focal myocardial pathology They tested this hypothesis in ..

Characterization Of Orbital Masses By Diffusion-Weighted Magnetic Resonance Imaging (DWI) And Apparent Diffusion Coefficient (ADC) Value

Abstract Objective To assess DWI and ADC value in characterization of orbital masses differentiation of benign inflammatory and malignant orbital masses Patients methods Crosssectional study included 38 patients and diagnosed histopathologically clinically and radiologically 26 with benign and ..

Cerebral Fat Embolism in a Trauma Patient with Captured Imaging of Echogenic Emboli in the Inferior Vena Cava

Abstract The authors present a case of fat embolism syndrome after traumatic longbone fracture in a patient with rapid neurologic deterioration and multiple cerebral embolic events Diagnostic workup revealed the neuroradiologic findings classically described with cerebral fat emboli The authors pre..

Defining Imaging Biomarker Cut Points For Brain Aging And Alzheimer's Disease

Abstract Introduction Our goal was to develop cut points for amyloid positron emission tomography PET tau PET flourodeoxyglucose FDG PET and MRI cortical thickness Methods We examined five methods for determining cut points Results The reliable worsening method produced a cut point only for am..

Vascular Image Registration Techniques: A Living Review

Abstract Registration of vascular structures is crucial for preoperative planning intraoperative navigation and followup assessment Typical applications include but are not limited to Transcatheter Aortic Valve Implantation and monitoring of tumor vasculature or aneurysm growth In order to achieve ..

Imaging findings of arthroereisis in planovalgus feet

Abstract Arthroereisis is a rare and disputed procedure where an implant screw is inserted into the sinus tarsi to treat flatfoot deformity Weightbearing radiographs are the most essential examinations to assess the correct localization and related measurements Hardware loosening is the most common..