Newest Issue is Out. Get your exclusive copy today.
This section focusses on the cutting-edge research and findings in the various disciplines of healthcare around the world.
Alcoholicrelated liver disease ALD is the cause of more than half of all liverrelated deaths Sustained excess drinking causes fatty liver and alcoholrelated steatohepatitis which may progress to alcoholic liver fibrosis ALF and eventually to alcoholrelated liver cirrhosis ALC Unfortunately it is difficult to identify patients with earlystage
Clinical evidence suggests a link between fibrosis in the left atrium LA and atrial fibrillation AF the most common sustained arrhythmia Imagederived fibrosis is increasingly used for patient stratification and therapy guidance However locations of reentrant drivers RDs sustaining AF are unknown and therapy success rates remain suboptimal
In order to assess the efficacy of novel HIV treatments leading to a functional cure the time to viral rebound is frequently used as a surrogate endpoint The longer the time to viral rebound the more efficacious the therapy In support of such an approach mathematical models serve as a connection
Metastases are the main reason for cancerrelated deaths Initiation of metastases where newly seeded tumor cells expand into colonies presents a tremendous bottleneck to metastasis formation Despite its importance a quantitative description of metastasis initiation and its clinical implications is lacking
We developed a computational platform including machine learning and a mechanistic mathematical model to find the optimal protocol for administration of platinumdoublet chemotherapy in a palliative setting The platform has been applied to advanced metastatic nonsmall cell lung cancer NSCLC
Inconsistent therapeutic efficacy of mesenchymal stem cells MSCs in regenerative medicine has been documented in many clinical trials Precise prediction on the therapeutic outcome of a MSC therapy based
Congestive heart failure is characterized by suppressed cardiac output and arterial filling pressure leading to renal retention of salt and water contributing to further volume overload Mathematical modeling provides a means to investigate the integrated function
Patients with opioid use disorder OUD who are hospitalized for serious infections requiring prolonged intravenous antibiotics may face barriers to discharge which could prolong hospital length of stay LOS and increase financial burden
Complex traumatic events associated with armed conflict forcible displacement childhood sexual abuse and domestic violence are increasingly prevalent People exposed to complex traumatic events are at risk of not only posttraumatic stress disorder
The allele of apolipoprotein E APOE gene and increasing age are two of the most important known risk factors for developing Alzheimer disease AD The diagnosis of AD based on clinical symptoms alone is known to have poor specificity
