Outcomes of the implementation of the computer-assisted HBView system for the prevention of hepatitis B virus reactivation in chemotherapy patients: a retrospective analysis

Authors: Akimasa Sanagawa, Junko Kuroda, Arufumi Shiota, Noriko Kito, Masashi Takemoto, Yoshihiro Kawade, Tetsuo Esaki and Kazunori Kimura

Abstract

Background

Screening for hepatitis B virus (HBV) infection is recommended worldwide for patients receiving systemic chemotherapy in accordance with clinical guidelines, but compliance varies by country and facility. Alert systems may be useful for promoting screening, but it is unclear how effective such systems are. In this study, we investigated HBV screening procedures and their incorporation into treatment regimens following the implementation of an alert system.

Methods

An alert system was introduced at our hospital in April 2012. The rates of HBV screening in the periods before and after the introduction of the alert system (September 2010 to March 2012 and April 2012 to October 2013, respectively) were investigated. We collected data on hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (HBsAb), hepatitis B core antibody (HBcAb), and HBV-DNA testing in patients. As a result of this analysis, we developed a system in which pharmacists would intervene to check and confirm whether HBV screening had occurred in patients scheduled to begin treatment with chemotherapy. We named our project the “HBView” project, and the rate of HBV screening and the number of times pharmacists intervened was studied during specific time periods before and after the HBView project commenced (July 2013 to December 2013 and January 2014 to June 2014, respectively).

Results

After introducing the alert system, the percentage of patients tested for HBsAb/HBcAb and HBV-DNA increased significantly, from 71.6 % to 84.9 % and from 44.5 % to 69.7 %, respectively. However, the rate of compliance with HBV testing guidelines was not 100 % after interventions. The numbers of patients who were not screened but should have been before and after the introduction of HBView were 6 and 17, respectively. Two patients at risk of HBV reactivation were identified after intervention by pharmacists; their intervention thus prevented HBV reactivation.

Conclusions

Compliance with clinical HBV screening guidelines was not sufficiently improved after the introduction of the automatic alert system; however, the HBView project proved useful in reinforcing the automatic alert system.

Keywords

HBV reactivation Cancer chemotherapy Computer-assist system Pharmacist intervention

Citation: Akimasa Sanagawa, Junko Kuroda, Arufumi Shiota, Noriko Kito, Masashi Takemoto et al. Outcomes of the implementation of the computer-assisted HBView system for the prevention of hepatitis B virus reactivation in chemotherapy patients: a retrospective analysis Journal of Pharmaceutical Health Care and Sciences20151:29 DOI: 10.1186/s40780-015-0030-7

Received: 21 August 2015  Accepted: 22 October 2015  Published: 4 November 2015

Copyright: © 2015 Sanagawa et al. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Competing interests

The authors declare that they have no competing interests.

Author contributions

AS (Sanagawa) carried out the survey of electronic records, prepared pharmacists’ intervention protocols, performed the statistical analysis, and drafted the manuscript. JK prepared pharmacists’ intervention procedures, helped draft the manuscript, and performed the survey of electronic records. AS (Shiota) helped perform the statistical analysis and draft the manuscript. NK helped survey the electronic records and draft the manuscript. MT prepared pharmacists’ interventions. YK and TE helped to draft the manuscript. KK conceived of the study, participated in its design and coordination, and helped to draft the manuscript. All authors read and approved the final manuscript.

Acknowledgements

We would like to thank Editage (www.editage.jp) for English language editing.

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