The new South Glasgow University Hospital campus cost more than £800m to build and will have more than 1,300 beds.
The health board said it had been delivered under budget and ahead of schedule.
The facility is due to open to patients in May.
Construction work began in early 2011 and it has been the biggest building site in Scotland.
The new campus will bring major changes to the way healthcare is delivered across the west of Scotland - with maternity, children's and adult hospitals all on one site.
The Southern General campus will replace the Southern General Hospital, Western and Victoria Infirmaries, Mansionhouse Unit and Royal Hospital for Sick Children at Yorkhill.
There will be space for 1,300 patients, mostly in single rooms, 29 operating theatres, and even a landing pad on the hospital roof, for rescue helicopters.
In addition to replacing adult hospitals in Glasgow, the new South Glasgow University Hospital will incorporate a new teaching and learning facility and the Centre for Stratified Medicine and clinical research facilities.
The chief executive of NHS Greater Glasgow and Clyde Robert Calderwood says the design is a move away from the traditional ward-based model.
"With the exception of critical care, all of the patient areas in the adult hospital are single ensuite rooms and all bedrooms have a full length floor to ceiling window on the outside wall to increase natural daylight but also to give the patient the opportunity to see outwith the clinical environment," he told Good Morning Scotland.
"In the children's hospital 80% of the 256 beds are singe, ensuite with parents' accommodation in the area."
Up to 10,000 NHS staff will be based on the campus when it is fully operational.
Building contractors, Brookfield Multiplex, are due to formally pass the hospital over to the health board later.